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Friday, July 31, 2020 | History

5 edition of Muscle gene therapy found in the catalog.

Muscle gene therapy

Dongsheng Duan

Muscle gene therapy

by Dongsheng Duan

  • 141 Want to read
  • 8 Currently reading

Published by Springer in New York .
Written in English

  • Duchenne Muscular Dystrophy,
  • Muscles,
  • Genetics,
  • Diseases,
  • Gene therapy,
  • Gene Therapy,
  • Therapy,
  • Methods

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Dongsheng Duan
    LC ClassificationsRC925.5 .M864 2010
    The Physical Object
    Paginationxvi, 275 p. :
    Number of Pages275
    ID Numbers
    Open LibraryOL25279398M
    ISBN 101441912053, 144191207X
    ISBN 109781441912053, 9781441912077
    LC Control Number2009933117

    Jerry R. Mendell, MD, is an attending neurologist at Nationwide Children's, principal investigator in the Center for Gene Therapy at The Research Institute of Nationwide Children's, Director of the Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, Co-director of the Muscular Dystrophy Association Clinic, Dwight E. Peters and Juanita R. Curran Endowed Chair in . Gene therapy (also called human gene transfer) is a medical field which focuses on the utilization of the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease. The first attempt at modifying human DNA was performed in by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed .

    The development of safer and more efficient gene transfer vectors and the advances on the cell therapy field have open new opportunities to tackle different diseases. The aim of this book is to bring together information about the different gene therapy tools, the clinical successes of gene therapy and the future by: A compelling new study, led by scientists from Washington University School of Medicine in St. Louis, has found a novel gene therapy can prevent obesity and build muscle without the need for additional exercise, in mice being fed a high-fat diet. quote: Follistatin, a protein expressed in .

      University of Missouri-Columbia. (, October 22). Gene therapy treats all muscles in the body in muscular dystrophy dogs: Human clinical trials are next step. ScienceDaily. Retrieved April   Canines were critical in developing gene-based treatments for Duchenne muscular dystrophy and a form of blindness (see the chapter “Kristina’s dogs” in my gene therapy book). Alison and Joshua In Alison and Paul learned, through their network of experts, of Nibs, a female chocolate lab living happily on a farm in Saskatoon, Saskatchewan.

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Muscle gene therapy by Dongsheng Duan Download PDF EPUB FB2

Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously.

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body.

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body.

In. Get this from a library. Muscle gene therapy. [Dongsheng Muscle gene therapy book -- Muscle disease represents an important health threat to the general population. For thousands of years, a cure has been deemed extremely remote, if not impossible, for many relentless muscle diseases.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Vol GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and.

Gene therapy has since been used experimentally to treat a number of conditions, including advanced metastatic melanoma, a myeloid disorder, and a rare hereditary condition that leads to severely impaired vision. Despite the hope that gene therapy can be used to treat cancer, genetic diseases, and AIDS, there are concerns that the immune system.

An updated overview of muscle gene therapy is provided in this comprehensive reference. The test highlights important gene therapy applications, in addition to the potential healing capabilities in complex genetic disorders. It brings human gene therapy out of the category of science fiction into the potential reality of congenital disease prevention Suggested readings at the end of each chapter and a glossary at the end of the book are helpful.

A thoughtful discussion of ethical and economic issues, particularly the probable cost of experimental therapies Author: Eve K.

Nichols. Provocatively written yet grounded in science, Unlock Your Muscle Gene is a revolutionary guide to physical transformation and the latest information on muscle conditioning, weight loss, and anti-aging strategies. According to Ori Hofmekler, we need to learn how to trigger the genes that retain and develop our muscles and extend our lives—we need to unleash this innate program that /5(34).

Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery. Researchers are testing several approaches to gene therapy, including: Replacing a mutated gene that causes.

Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed.

– Book editor for “Muscle Gene Therapy” (Springer, New York, NY) – Member, Muscular Dystrophy Association (MDA) Scientific Advisory Committee – Chancellor’s Award for Outstanding Research and Creative Activity, University of Missouri.

Gene therapy introduces transgenic cells either into somatic tissue to correct defective function (somatic therapy) or into the germ line for transmission to descendants (germ-line therapy).

By agreement with the publisher, this book is accessible by. Limb-girdle muscular dystrophy (LGMD) is a purely descriptive term, generally reserved for childhood- or adult-onset muscular dystrophies that are distinct from the much more common X-linked dystrophinopathies. LGMDs are typically nonsyndromic, with clinical involvement typically limited to skeletal muscle.

Individuals with LGMD generally show Cited by: Muscle-Targeted Gene Therapy of Charcot Marie-Tooth Disease is Dependent on Muscle Activity. By Stephan Klossner, Marie-Noëlle Giraud, Sara Sancho Oliver, David Vaughan and Martin Flück. Submitted: October 27th Reviewed: April 3rd Author: Stephan Klossner, Marie-Noëlle Giraud, Sara Sancho Oliver, David Vaughan, Martin Flück.

Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders.

AAV is of great interest for muscle gene therapy as it efficiently infects skeletal muscle and can persist for years, at least in healthy mice (49,50). Persistence is likely a result of nuclear retention signals in the vector genome, since recombinant AAV does not appear to integrate to an appreciable extent (51).Cited by: These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy.

Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte. “There are now ways to develop drugs for people who are unable to exercise due to obesity or other health complications, such as diabetes, immobility and frailty,” says Ronald M.

Evans, a professor in Salk’s Gene Expression Lab, who led the Salk team.“We can now engineer specific gene networks in muscle to give the benefits of exercise to sedentary mice.”.

Gene injections in rats can double muscle strength and speed, researchers have found, raising concerns that the technology could be used illegally to build super : Paul Recer. Duchenne muscular dystrophy (DMD) is a devastating, degenerative muscle disease that affects ~1 in every male births.

DMD arises from mutations in the DMD gene that prevent expression of its.Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and humans it is encoded by the MSTN gene.

Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein Aliases: MSTN, GDF8, MSLHP, myostatin.

Researchers have found a delivery method for gene therapy that reaches all the voluntary muscles of a mouse – including heart, diaphragm and limbs – and reverses the process of muscle-wasting.